Ultrasound-Responsive Azide Nano-prodrugs Enable Spatiotemporal Activation of TLR7/8 Agonists for Tumor Therapy

6 days ago 17

Biomater. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5BM00755K, Paper

Open Access

&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chuwen Luo, Chaoying Kong, Yuxiao Zhang, Yajun Xu, Zhaohui Tang
Systemic immunotoxicity caused by off-target activation is still a critical obstacle to clinical translation of imidazoquinoline (IMDQ) drugs, a kind of TLR7/8 agonists. Here, we present an ultrasound-responsive, azide-modified IMDQ...
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