Calcium-binding PLGA microparticles releasing rhBMP-2 for enhancement of bone healing with minimal ectopic bone formation in spine fusion

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Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01536G, Paper
Open Access Open Access
Minjae Kim, Jungwoo Kim, Minji Kang, So Hee Nam, Chi Heon Kim, Yan Lee, Sung Bae Park
We designed a delivery vehicle that locally maintains recombinant human bone morphogenetic protein-2 (rhBMP-2) at bone surgery sites to enhance bone healing while minimizing excessive bone formation at non-targeted sites.
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